Viral-mediated Oct4 overexpression induces direct conversion of wildtype mammalian Müller glia to bipolar neurons, and this process is synergistically enhanced by loss of Notch signaling.

Presynaptic NMDA receptors can shape timing-dependent long-term depression in a way that departs from their classic postsynaptic role.

Life has been announced as a winner in the first Crossref Metadata Awards, recognising its commitment to high-quality ...

This important study provides insights into the role of maternal behavior in the learning and ontogeny of vocalization. It finds evidence that the maternal behavior of sac-winged bats (Saccopteryx ...

eLife is a non-profit organisation inspired by research funders and led by scientists. Our mission is to help scientists accelerate discovery by operating a platform for research communication that ...

Resurrection of ancient forms of CD4 reveals how retroviruses have placed selective pressure on this gene in apes, acting to propagate infection-resistant alleles.

Efforts to estimate the reproducibility of published research results have focused on specific areas of research to date, such as cancer biology and psychology. The Brazilian Reproducibility ...

This valuable study focuses on defining how the HSP70 chaperone system utilizes J-domain proteins to regulate the heat shock response-associated transcription factor HSF1. Using a combination of ...

Diane M Harper, MD, MPH, MS, completed her undergraduate and graduate degrees at the Massachusetts Institute of Technology in Cambridge, Massachusetts, in the fields of Chemical Engineering and ...