Antibody–siRNA conjugates (ARCs) are a type of promising drug modalities for cancer therapy. However, initial reports of ARCs present the gene knockdown effect only in limited tissues (e.g., muscles) ...

The rapid identification of respiratory virus outbreaks is needed to enable rational and effective public health interventions. We developed new quantitative approaches for simultaneous ...

Facilities operated by the US Department of Energy (DOE) are required to have extensive worker safety and health programs by regulation. We describe how Argonne National Laboratory (ANL) has ...

TOPICS & COLLECTIONS ACS Curated Content ACS Curated Content helps you discover topics that fascinate you and keep you up-to-date with the latest research in your field. Covering a connected body of ...

Announcing ACS Nano Medicine We’re excited to announce our new journal— ACS Nano Medicine —a new addition to the family of ACS journals. “The broad scope of ACS Nano Medicine, encompassing fundamental ...

Targeted protein degradation (TPD) has emerged as a promising therapeutic strategy for treating various diseases. However, current small molecule degraders predominantly rely on a limited set of E3 ...

MDM2 is a key negative regulator of the tumor suppressor p53 and an attractive target for cancer therapy. We report the discovery of MD-4251, the first orally efficacious MDM2 degrader developed using ...

The role of interfacial water and hydrogen-bonding structures in an electric double layer (EDL) in alkaline hydrogen oxidation reaction (HOR) kinetics has garnered widespread attention. However, the ...

Direct synthesis of acid–base-stable copper carboxylate metal–organic frameworks (MOFs) is of great significance but faces substantial challenges. Herein, a nanoenvelope strategy was proposed to ...

The observation of increasing lithium-ion transference numbers upon increasing anion size has been frequently reported in the literature. While in dilute systems this can be explained by reduced ...

Perovskite quantum dots (PeQDs) have garnered significant attention as new-generation color-conversion materials for potential applications in microlight-emitting-diode (micro-LED)-based display ...

Hybrid organic–inorganic perovskites have garnered significant attention in optoelectronics due to their exceptional optical and electrical properties. Among them, low-dimensional chiral perovskites ...